Endocrine Abstracts

Introduction: To date, psychological research on pancreatic transplantation has focused mainly on illness and quality of life. Research has been predominantly quantitative rendering it impossible to identify specific psychological issues faced by patients. Uniquely, this work considered post-transplant issues in the context of the pre-transplant psychological burden of patients with T1DM.Methods: 21 individuals with T1DM were interviewed (11 males; five ...

Islet transplantation, an effective treatment for Type I Diabetes, is compromised by transient ischemia. Ischemia reduces the viability and function of transplanted islets and may also promote signals that lower islet efficacy. In order to characterize the response of human islets to transient ischemia, high-throughput sequencing was employed to determine global gene expression. Islets isolated from healthy donors (n=4) were either pelleted in microcentrifuge tubes (i...